Crosslinking of dermal sheep collagen using hexamethylene diisocyanate

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Cross-linking of dermal sheep collagen using a water-soluble carbodiimide.

A cross-linking method for collagen-based biomaterials was developed using the water-soluble carbodiimide 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide hydrochloride (EDC). Cross-linking using EDC involves the activation of carboxylic acid groups to give O-acylisourea groups, which form cross-links after reaction with free amine groups. Treatment of dermal sheep collagen (DSC) with EDC (E-DSC)...

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ژورنال

عنوان ژورنال: Journal of Materials Science: Materials in Medicine

سال: 1995

ISSN: 0957-4530,1573-4838

DOI: 10.1007/bf00120286